部分肿瘤标志物在常见慢性病患者中的异常表达

Abnormal Expression of Some Tumor Biomarkers in Patients with Common Chronic Diseases

目的分析CA242、CA199、CA724、CA125在常见慢性病患者中的异常表达特点。方法选本院住院治疗的常见慢性病(糖尿病、高血压病、冠心病、心力衰竭、慢性阻塞性肺病、肺源性心脏病合并心力衰竭)患者共457例,健康体检的正常对照组199例;取外周血3ml,分离血清,全自动化学发光仪检测CA242、CA199、CA724、CA125、CYFRA21-1和CA50指标,统计分析这些肿瘤标志物在无肿瘤的常见慢性疾病患者中异常表达特点。结果糖尿病合并并发症患者组,CA242为8.10±5.14U/ml、CA199为20.30±17.00U/ml,与正常对照组比差异有统计学意义(P<0.01),CA125和CA724水平与对照组相比差异无统计学意义(P>0.05);冠心病患者组、心力衰竭患者组、慢性阻塞性肺病患者组和肺源性心脏病合并心力衰竭患者组,CA724分别为5.86±4.38U/ml、40.46±47.14U/ml、4.58±2.19U/ml和32.11±30.54U/ml,CA125分别为11.50±9.71U/ml、111.91±104.29U/ml、9.89±9.21U/ml和90.97±95.18U/ml,与正常对照组比差异有统计学意义(P<0.01),CYFRA21-1和CA50水平与对照组相比差异无统计学意义(P>0.05)。结论 CA242、CA199在糖尿病合并并发症患者及CA724、CA125在冠心病、心力衰竭、慢性阻塞性肺病和肺源性心脏病合并心力衰竭患者中,均有异常升高,提示这些肿瘤标志物在临床应用中,有必要排除常见慢性病导致的升高。

Objective To explore the abnormal expression of CA242,CA199,CA724,CA125 in patients with common chronic disea- ses. Methods Totally 457 cases of patients with common chronic diseases, such as diabetes mellitus,hypertension,coronary heart disease, heart failure, chronic obstructive pulmonary diseases, cor pulmonale eommbined with heart failure were selected in hospital. 199 cases of control group come from health examination people. The serum of peripheral blood were seperated and CA242,CA199 ,CA724 ,CA125, CYFRA21 - 1 and CA50 were detected using automatic chemiluminescence instrument. The data of these tumor related biomarkers were analysed in the patients with common chronic diseases. Results The serum CA242 and CA199 level in diabetes mellitus patients were 8. 10 ± 5.14U /ml and （20.30 ± 17.00）U/ml seperately. It had a significant difference compared with control group（ P 〈 O. 01 ） , and the CA125 and CA724 level had no difference with control group（P 〉 0.05）. The serum CA724 and CA125 in coronary heart disease group, heart failure group,chronic obstructive pulmonary diseases group,cor pulmonale commbined with heart failure group were 5.86 ± 4.38U/ ml,40.46 ±47.14U/ml,4.58 ± 2.19U/ml,32.11 ± 30.54U/ml and 11.50± 9.71U/ml, 111.91 ± 104.29U/ml, 9.89 ± 9.21U/ml and 90.97 ± 95.18U/ml. They all had a significant difference compared with control group（ P 〈 0. 01 ） , and the CYFRA21 - 1 and CA50 lev- el had no difference with control group（P 〉0.05）. Conclusion The CA242 and CA199 level in patients of diabetes mellitus combined with complications, the CA724 and CA125 level in patients with coronary heart disease,heart failure,chronic obstructive pulmonary disea- ses,cor pulmonale commbined with heart failure increased abnormally. It prompted that it was necessary to eliminate the abnormal increas- ing in patients with chronic diseases when diagnosis with these tumor related biomarkers.