摘要
目的探讨有创动脉压持续监测时冲洗肝素对患者凝血功能及出血的影响。方法取择期普胸外科及普外胃肠科手术患者(ASAⅠ~Ⅱ),随机分为3组:肝素0.1U/kg组、肝素0.5U/kg组、肝素1.0U/kg组,动脉穿刺置管后给予各组相应的处理,记录各组术中第1、2、3h的凝血功能,比较各组参数的差异。结果与术前相比较,活化部分凝血活酶时间(APTT)和国际标准化率(INR)比术前有所延长,但是无统计学意义(P>0.05),且值在正常范围内(P>0.05)。结论微量肝素术中冲洗对患者术中的出凝血功能无显著影响,不会增加硬膜外阻滞引起硬膜外血肿的风险。
Objective To study the influence of micro - heparin flushes on blood coagulation. Methods The blood samples were collected every one hour after arteriopuncture from patients (ASA Ⅰ-Ⅱ ) who underwent the selective surgeries (thoracic surgery and Gastric & Intestine). They were allocated to three heparin groups (0.1U/kg, 0.5U/kg and 1.0U/kg) groups. After arteriopuncture, the heparin was administrated intermittently through arterial line in different groups. Blood samples were obtained to measure the blood coagu- lation from the peripheral vein every 1 hour after the arteriopuncture. Results Aptt and INR was longer than those before the operation, but no significant difference (P 〉 0.05) was found among the groups and all of coagulation was in normal range. Conclusion Continuous micro - heparin flush do not affect the blood coagulation during the continuous arterial blood pressure monitoring.
出处
《医学研究杂志》
2012年第6期122-124,共3页
Journal of Medical Research
关键词
凝血功能
肝素
直接动脉压监测
硬膜外血肿
Blood coagulation
Heparin
Continuous arterial blood pressure
Epidural hematoma