非糜烂性胃食管反流病患者不同治疗方案评价

Evaluation of Different Treatment Protocols of NERD

目的比较以抑酸剂为基础的不同联合用药方案治疗非糜烂性胃食管反流病(NERD)的效果,为临床用药提供指导。方法将53例NERD患者随机分为4组,分别给予抑酸剂(A组)、抑酸剂+利胆药(B组)、抑酸剂+促动力药(C组)、抑酸剂+利胆药+促动力药(D组)等4种方案治疗8周,并记录各组患者治疗前、治疗后第4周、第8周症状评分。然后比较各组治疗前后症状评分的差异以及组间治疗效果的差异。结果 4组患者治疗后第4周、第8周症状评分均降低,差异有统计学意义(P<0.05)。治疗后,D组患者症状评分降低最明显,显著低于其他3组,差异有统计学意义(P<0.05)。结论在NERD的治疗中,以抑酸剂为基础的联合用药效果要优于单用抑酸剂者,而抑酸剂联合促动力药及利胆剂治疗NERD可使治疗效果达到最佳。

Objective To compare the clinical results of different treatment protocols basing on acid inhibitor of non- crosive gastroesophageal reflux disease （NERD） , and direct the clinical works. Methods 53 patients with NERD were divided into 4 groups, and 4 treatment protocols. Acid inhibitor, acid inhibitor ＋ cholagogue, acid inhibitor ＋ dynamics- promoting medi- cine, and acid inhibitor ＋ cholaegogue ＋ dynamics- promoting medicine,were given to group A, B, C and D respectively, and the treatment course was 8 weeks. The symptom score of each group was record at such point as pre-treatment,4 weeks after treat- rrlent, and 8 weeks after treatment. Compared the difference of the symptom scores of each group to find the difference between e^ch treatment protocol. Results The symptom scores of 4 weeks and 8 weeks after treatment of 4 groups declined obviously, compared with those of pre- treatment, the difference was significant （ P 〈 0.05 ）. And the post- treatment symptom score of D group was lower than those of other 3 groups, the difference was significant （P 〈 0.05 ）. Conclusion In treatment of NERD, a treatment protocol basing on acid inhibitor can get a better result than that of single acid inhibitor, and acid inhibitor ＋ cholae- gogue ＋ dynamics promoting medicine can get the best result in the 4 protocols we observed.