肝硬化患者Child-Pugh分级与体表心电图QTc的相关性研究

The relationship between Child-Pugh grade of liver cirrhosis and rate-corrected QT interval of electrocardiogram

目的探讨肝硬化患者体表心电图校正QT间期时间变化及其与Child-Pugh分级之关系。方法对30例肝硬化患者和对照组进行QTc等多项指标的对比分析,并研究不同Child-Pugh分级的肝硬化患者的QTc。结果肝硬化患者心电图存在多种异常,其中QTc和对照组比较明显延长分别为(0.447±0.031)s和(0.372±0.038)s,P=0.000。且QTc和Child-Pugh分级相关,分级越高,QTc越长。A级:(0.427±0.013)s;B级:(0.446±0.024)s;C级:(0.468±0.038)s。Spearman相关系数0.550,P=0.002;Kendall相关系数0.443,P=0.003。结论肝硬化患者存在多种心电图异常,QTc与其严重程度相关。

Objective To investigate the relationship between Child-Pugh grade of liver cirrhosis patients and ratecorrected QT interval（QTc）of electrocardiogram. Methods Compared with the normal controls,electrocardiogram of 30 liver cirrhosis patients are analyzed. The relationship between QTc and Child-Pugh grade was analyzed. Results The electrocardiogram of liver cirrhosis patients has many kinds of ahnormality.QTc was more prolonged than the normal controls（0.447 ± 0.031 s vs 0.372± 0.038 s,P=0.000）. QTc was positively correlated with Child-Pugh grade.A grade （0.427 ±0.013） s;B grade （0.446± 0.024） sic grade （0.468 ± 0.038） s;Spearman 0.550,P=0.002;Kendall 0.443,P=0.003）. Conclusion The electrocardiogram of liver cirrhosis patients has many kinds of abnormality.QTc was positively correlated with the severity of liver cirrhosis.