摘要
在细胞正常生理状态下,凋亡诱导因子定位在线粒体内膜上,与呼吸链复合体Ⅰ互相作用,催化电子从泛醌到细胞色素C的传递。当细胞受到凋亡信号刺激后,凋亡诱导因子变成可溶性蛋白,从线粒体释放到细胞浆中,再通过其核定位信号序列进入细胞核内,和其他因子一起作用于染色体,使染色体凝聚和DNA呈大片段断裂(约50kb),最终诱导细胞凋亡。凋亡诱导因子受p53、Bcl-2家族、Hsp70等多种因子的调节。
Apoptosis-inducing factor is located in the mitochondrial inner membrane in cell normal physiological state. It catalysis electron transmit between ubiquinone and cytochrome c with complex I. When apoptosis stimuli present, AIF becomes soluble protein and is released from mitochondria to cytoplasm and then to nucleus through its nuclear localization sequence, resulting in condensation of chromatin and large scale fragmentation of DNA （about 50 kb） possible with other proteins. Many cell factors such as Calpain, Bcl-2 family and Hsp70 regulate AIF.
出处
《中国医药科学》
2012年第10期32-33,共2页
China Medicine And Pharmacy
关键词
凋亡诱导因子
细胞凋亡
线粒体
Apoptosis-inducing factor
Irregular menstruation
Apoptosis
Mitochondrial
