系统性红斑狼疮合并心血管疾病的临床研究

Clinical study of systemic lupus erythematosus patients with cardiovascular disease

目的探讨系统性红斑狼疮合并心血管疾病患者的临床及实验室指标特点及其临床意义。方法回顾性分析144例SLE患者的临床及实验室指标,及其与心血管疾病发生的相关性。结果 144例SLE患者中,60例(41.6%)合并心血管疾病。心脏损害组与心脏未受损害组比较,两组间年龄、病程差异具有统计学意义;且心脏损害组的SLE患者的血红蛋白明显低于心脏未损害组,而C反应蛋白明显高于未损害组(P<0.05)。结论病程长、贫血及CRP增高可能会增加SLE患者合并心血管疾病的发生率,可以作为患者病情判断、预后评估的指标。

Objective To investigate the clinical and laboratory characteristics in systemic tupus elytll^ulutuaua lJ combined cardiovascular disease,and their clinical significance. Methods Retrospective review comparison analyze the clinical and laboratory characteristics of 144 cases with SLE,and the correlation with the chances of cardiovascular disease. Results 144 cases of SLE patients,60 patients （41.6%） combined with cardiovascular disease. Impaired cardiac group compared to non-impaired group：age,course of disease were statistically significant differences.Cardiac damage in patients with SLE hemoglobin was significantly lower than that does not damage the heart group, and C-reactive protein was significantly higher than non-damaged group, the difference was statistically significant （P〈0.05）. Conclusion The course of disease , anemia and elevated CRP in patients with SLE may increase the chances of cardiovascular disease combined, and it can also help discriminate and diagnose early stage.