达英-35联合生活方式调整对肥胖型多囊卵巢综合征生殖内分泌和脂代谢的影响

Clinical effect of Diane-35 combined modification of life style on the reproductive endocrine and lipid metabolize in obese polycystic ovary syndrome

目的探讨达英-35联合生活方式调整对肥胖型多囊卵巢综合征的临床治疗疗效。方法选择2009年5月～2011年5月到笔者所在医院就诊的79例肥胖型多囊卵巢综合征患者,分为实验组45例,给予达英-35联合生活方式调整治疗;对照组34例,单给予达英-35治疗。比较两组治疗前后的生殖内分泌和脂代谢等指标的变化及促排卵情况。结果经治疗后两组的生殖内分泌、脂代谢指标均有下降,实验组下降更为明显,差异有统计学意义(P<0.05)。治疗组的排卵率及受孕率均高于对照组,差异有统计学意义(P<0.05)。结论达英-35联合生活方式调整治疗肥胖型多囊卵巢综合征可明显改善患者的生殖内分泌和脂代谢情况,提高患者的排卵率和受孕率。

Objective To explore the elinical effect of the treatment of Diane-35 combined modification of life style on reproductive endocrine and lipid metabolize in obese polycystic ovary syndrome. Methods 79 patients with obese polycystic ovary syndrome from May 2009 to May 2011 were seleeted and divided into two groups randomly. Observation group （45 patients） underwent Diane-35 combined modification of life style and control group（34 patients） only treated with Dinae-35. Comparison was made between two groups in items of endoerine system and the ovulation. Results Two groups both have improved in LH, T, LH/FSH, BMI, FBS, FINS, TG. Observation group has a better clinical effeet than eontrol group, and has statistical signifieanee. Gonelusion Diane-35 combined modification of life style has better clinical effeet, and could enhance the rate of ovulation and impregnation.