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前列腺素E_2在骨形成过程中的作用机制 被引量：1

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摘要 骨形成是一个由多种因素调节的复杂而有序的过程。前列腺素E2（PGE2）由机体产生，在全身各器官均发挥广泛作用，其促进骨形成的作用主要通过其受体介导，并与剂量、药物协同等因素相关，国内外学者也从不同角度对此进行了探索。现将PGE2在骨形成过程的具体作用机制的研究进展作一综述。
作者 王欢 查振刚
机构地区 暨南大学附属第一医院骨科 暨南大学骨科疾病研究所
出处 《广东医学》 CAS CSCD 北大核心 2012年第11期1683-1685,共3页 Guangdong Medical Journal
关键词 前列腺素E2 骨形成 受体介导 PGE2 国内外
分类号 R719.31 [医药卫生—妇产科学]
  • 相关文献

参考文献20

  • 1YOSHIDA K,OIDA H,KOBAYASHI T. Stimulation of bone formation and prevention of bone loss by prostaglandin E EP4 receptor activation[J].Proceedings of the National Academy of Sciences(USA),2002,(07):4580-4085.
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  • 5朱森,杨吉春,管又飞.前列腺素E_2受体亚型EP_2和EP_4的最新研究进展[J].临床医学工程,2009,16(7):109-112. 被引量：18
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二级参考文献12

  • 1Biswas S,Bhattacherjee P,Paterson CA,et al.Ocular inflammatory re-sponses in the EP2and EP4receptor knockout mice[].Ocul Immunol In-flamm.2006
  • 2Hosl K,Reinold H,Harvey RJ.Spinal prostaglandin E receptors of the EP2subtype and the glycine receptorα3subunit,which mediate central inflammatory hyperalgesia,do not contribute to pain after peripheral nerve injury or formalin injection[].Pain.2006
  • 3Pavlovic S,Du B,Sakamoto K.Targeting prostaglandin E2receptors as an alternative strategy to block cyclooxygenase-2-dependent extracellu-lar matrix-induced matrix metalloproteinase-9expression by macrophages[].Journal of Biological Chemistry.2006
  • 4Audoly LP,Ruan X,Wagner VA,et al.Role of EP2and EP3PGE2recep-tors in control of murine renal hemodynamics[].American Journal of Physiology Heart and Circulatory Physiology.2001
  • 5Chen J,Zhao M,He W,et al.Increased dietary NaCl induces renal medullary PGE2production and natriuresis via the EP2receptor[].American Journal of Physiology Renal Physiology.2008
  • 6John D Imig,Matthew D.Breyer,Richard M.Breyer.Contribution of prostaglandin EP2receptors to renal microvascular reactivity in mice[].American Journal of Physiology Renal Physiology.2002
  • 7Hristovska AM,Rasmussen LE,Hansen PB,et al.Prostaglandin E2In-duces Vascular Relaxation by E-Prostanoid4Receptor-Mediated Acti-vation of Endothelial Nitric Oxide Synthase[].Journal of Hypertension.2007
  • 8Yuhki K,Ueno A,Naraba H.et al.Prostaglandin Receptors EP2,EP3,and IP Mediate Exudate Formation in Carrageenin-Induced Mouse Pleurisy[].Journal of Pharmacology and Experimental Therapeutics.2004
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  • 10TOH, H.,A. ICHIKAWA,,AND S. NARUMIYA.Molecular evolution of receptors for eicosanoids[].FEBS Lett.1995

共引文献20

同被引文献8

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二级引证文献3

广东医学
2012年 第11期

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