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急性心力衰竭患者血浆NT-proBNP水平与胸腔内血容量指数的相关性 被引量：9

The correlation between plasma NT-proBNP level and intrathoracic blood volume index in acute heart failure patients
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摘要 目的评估急性心力衰竭患者血浆NT-proBNP水平与胸腔内血容量指数(ITBVI)的相关性,根据血浆NT-proBNP水平初步判断急性心力衰竭患者血流动力学状态,以指导液体治疗。方法选取NYHA分级≥Ⅲ级或Killip分级≥Ⅱ级急性心力衰竭患者36例,在行PICCO监测后1、24、48 h测定患者的ITBVI、NT-proBNP水平和中心静脉压(CVP),计算ITBVI和NT-proBNP、CVP之间的相关系数。结果 NT-proBNP水平随着ITBVI升高而升高,呈正相关(r=0.701,P<0.05);NT-proBNP水平越高,每搏量指数(SVI)越低,呈负相关(r=-0.405,P<0.05);CVP与NT-proBNP、ITBVI的相关性无统计学意义(r=0.182,P>0.05;r=0.054,P>0.05)。结论急性心力衰竭患者NT-proBNP浓度越高,心脏泵血功能越差,心脏容量超负荷的风险越大;CVP对急性心力衰竭患者心脏容量负荷评估准确性差,不适合单独作为评估心力衰竭患者容量负荷状态的参考指标。 Objective To study the correlation between plasma NT - proBNP level and intrathoracic blood volume index in acute heart failure patients, thus to assess the clinical significance of plasma NT - proBNP in AHF. Methods 36 patients with AHF （ NYHA ≥ Ⅲ or Killip ≥ Ⅱ ） were included. The ITBVI, plasma NT - proBNP and IVP were as- sessed 1, 24 and 48 hours after receiving PICCO monitoring for analysis. Results NT - proBNP was significantly posi- tively correlated with ITBVI （r =0. 701, P 〈0. 05） , while negatively correlated with stroke volume index （SVI） （r = - 0. 405, P 〈 0. 05 ）. There was no significant correlation revealed between CVP and NT- proBNP （r = 0. 182, P 〉 0. 05 ） or ITBVI （ r = 0. 054, P 〉 0. 05 ）. Conclusion In AHF patients, the higher NT - proBNP suggests the worse cardiac function and the greater risk of volume overload. CVP monitor alone is insufficient in assessing volume overload.
作者 邓梦华 马明远 陈次滨 江浩波 张云海
机构地区 广东省佛山市中医院ICU 广州医学院第三附属医院心内科
出处 《广东医学》 CAS CSCD 北大核心 2012年第12期1723-1725,共3页 Guangdong Medical Journal
基金 广东省佛山市卫生局科技项目(编号:2010110)
关键词 急性心力衰竭 胸腔内血容量指数 NT-PROBNP 中心静脉压 scute heart failure intrathroraeic blood volume index NT- proBNP central venous pressure
分类号 R605.971 [医药卫生—急诊医学]
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参考文献13

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同被引文献72

  • 1胡建,许运帆,韩宁,等.正压通气在老年急性心力衰竭患者中的疗效分析[J].中国急救医学,2013,33(21):57-58.
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引证文献9

二级引证文献57

广东医学
2012年 第12期

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