参芪扶正注射液对癌症恶病质小鼠血脂的影响

Influence of Shenqi Fuzheng injection on blood lipids in mice with cancer cachexia

[目的]观察参芪扶正注射液对癌症恶病质小鼠恶病质状态的影响,探讨参芪扶正注射液治疗癌症恶病质的作用机制。[方法]建立C57小鼠癌症恶病质模型,观察参芪扶正注射液对恶病质小鼠的一般状况,如体质量、摄食量、饮水量的影响;观察血清中甘油三酯(TG)和胆固醇(CHOL)的水平变化。[结果]参芪扶正注射液能明显增加癌症恶病质小鼠摄食量及饮水量,抑制体质量下降(P<0.05);可显著抑制血清中TG和CHOL的异常升高。[结论]参芪扶正注射液对小鼠的癌症恶病质有明显的改善作用,其作用机制可能与其抑制脂肪分解有关。

[Objective] To observe the effect of Shenqi Fuzheng injection in mice with cancer cachexia and study its mechanism.[Methods] The model of cancer caxhexia was established in C57 mice and the changes of physiological conditions（body weight,food and water intake） and the levels of triglyceride（TG） and cholesterol（CHOL） were observed.[Results] Shenqi Fuzheng injection could significantly increase water and food intake of mice with cancer cachexia and inhibit the loss of body weight（P〈0.05） and the abnormal increasing of TG and CHOL.[Conclusion] Shenqi Fuzheng injection can significantly improve the cancer caxhexia in cancer mice,and its mechanism may be related to the inhibition of lipolysis.