摘要
目的:为研究洛伐他汀新剂型,制备洛伐他汀新型前体脂质体,并对其质量进行考察。方法:采用一种新型前体脂质体制备方法将洛伐他汀制成自组装前体脂质体,对水合后脂质体的形态、粒径、Zeta电位、包封率、自组装速度、稳定性等进行考察,验证这种新型前体脂质体制备方法用于制备洛伐他汀脂质体的可行性。结果:所形成的洛伐他汀脂质体包封率为95.4%±6.7%,平均粒径为(327.4±29.6)nm,Zeta电位值为-(22.4±1.5)mV。洛伐他汀自组装前体脂质体可在60 s内自发形成脂质体并达到分散平衡;以人工胃液为稀释介质,洛伐他汀脂质体在12 h内稳定。结论:采用新型前体脂质体制备方法可将洛伐他汀制成洛伐他汀脂质体,形成的脂质体包封率较高且具有良好的稳定性。
To investigate the possibility of liquid proliposomes being carriers for oral delivery,lovastatin self-assemble proliposomes were prepared.Lovastatin proliposomes were characterized by conversion rate from proliposomes to liposomes,entrapment efficiency（EE,%）,particle size and shape,zeta potential and stability.Results showed that lovastatin proliposomes were automatically converted into liposomes when exposed to a water phase in 60 s.The average diameter was 327.4±29.6 nm in distilled water with entrapment efficiency of 95.4±6.7%,zeta potential of-（22.4±1.5） mV.The stability study showed that entrapment efficiency and particle size of lovastatin liposomes remained unchanged for 12 h.
出处
《药学与临床研究》
2012年第3期181-184,共4页
Pharmaceutical and Clinical Research
关键词
洛伐他汀
前体脂质体
包封率
Lovastatin
Proliposomes
Entrapment efficiency
