期刊文献+

非酒精性脂肪性肝病的脂质组学研究 被引量:2

下载PDF
导出
摘要 非酒精性脂肪性肝病(NAFLD)以肝细胞的脂肪堆积为其最常见的肝脏病理学特征,并常伴有代谢综合征或胰岛素抵抗,与肥胖、糖尿病、高胰岛素血症、血脂异常和高血压相关,但其机制仍不清楚。最近,通过高通量脂质组学研究来阐明NAFLD的发病机制,能更好地指导临床上对NAFLD的早期干预及治疗。
出处 《国际消化病杂志》 CAS 2012年第3期132-133,137,共3页 International Journal of Digestive Diseases
基金 国家973计划(2012CB524905)
  • 相关文献

参考文献16

  • 1Clark JM. The epidemiology of nonalcoholic fatty liver disease in adults. J Clin Gastroenterol, 2006, 40:S5- S10.
  • 2Pagano G, Pacini G, Musso G, et al. Nonalcoholic steatohe patitis, insulin resistance, and metabolic syndrome: further evidence for an etiologic association. Hepatology, 2002, 35: 367 372.
  • 3Gupte P, Amarapurkar D, Agal S, et al. Non-alcoholic steatohepatitis in type 2 diabetes mellitus. J Gastroenterol Hepatol, 2004, 19: 854-858.
  • 4Begriche K, Igoudjil A, Pessayre D, et al. Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it. Mitoehondrion, 2006, 6: 1-38.
  • 5Han X, Gross RW. Global analyses of cellular lipidomes directly from crude extracts of biological samples by ESI mass spectrometry: a bridge to lipidomics. J Lipid Res, 2003, 44: 1071-1079.
  • 6Lagarde M, Geloen A, Record M, et al. Lipidornics is emerging. Biochim Biophys Acta, 2003, 1634: 61.
  • 7Lee SH, Williams MV, DuBois RN, et al. Targeted lipidomics using electron capture atmospheric pressure chemical ionization mass spectrometry. Rapid Commun Mass Spectrom, 2003, 17: 2168-2176.
  • 8Esch SW, Williams TD, IBiswas S, etal. Sphingolipid profile in the CNS of the twitcher (globoid cell leukodystrophy) mouse: a lipidomics approach. Cell Mol Biol (Noisyqe-grand), 2f)03, 49: 779 787.
  • 9Purl P, Wiest MM, Cheung O, et al. The plasma lipidomic signature of nonalcoholic steatohepatitis. Hepatology, 2009, 50: 1827- 1838.
  • 10Gonzalez Periz A, Horrillo R, Ferre N, et al. Obesity-induced insulin resistance and hepatic steatosis are alleviated by omega-3 fatty acids: a role for resolvins and proteetins. FASEB J, 2009, 23:1946 1957.

同被引文献15

引证文献2

二级引证文献3

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部