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Min基因突变鼠模型在筛选FAP防治药物中的应用 被引量：1

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摘要 家族性结肠腺瘤性息肉病(FAP)是一种以消化道多发性腺瘤性息肉为特征的常染色体显性遗传病,其发病主要与腺瘤性息肉病基因(Apc)突变有关。目前尚缺乏疗效理想和安全的FAP防治方法。Min基因突变鼠模型携带Apc突变基因,是FAP防治研究及新药筛选评价的经典模型。此文就近年来应用Apc Min/+小鼠模型筛选出的可用于防治FAP的药物和饮食等因素进行汇总,并对其可能的作用机制作一综述。
作者 张慧 曹海龙 王邦茂
机构地区 天津医科大学总医院消化科
出处 《国际消化病杂志》 CAS 2012年第3期169-171,共3页 International Journal of Digestive Diseases
基金 国家自然科学基金资助项目(81070283)
关键词 家族性结肠腺瘤性息肉病 Min小鼠 药物治疗
分类号 R735.3 [医药卫生—肿瘤]
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参考文献25

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同被引文献22

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国际消化病杂志
2012年 第3期

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