吸收促进剂对水飞蓟宾及其磷脂复合物肠吸收的影响

Effect of Absorption Enhancers on Intestinal Absorption of Silybin and its Phospholipid Complex

目的:考察吸收促进剂对水飞蓟宾及其磷脂复合物肠道吸收的影响。方法:采用大鼠在体单向肠灌流法研究药物在大鼠的十二指肠、空肠、回肠及结肠的吸收情况。结果:水飞蓟宾及其磷脂复合物在各肠段均有吸收,以空肠和回肠段吸收较好,且其磷脂复合物在各肠段吸收均高于药物本身。聚山梨醇酯对水飞蓟宾及其磷脂复合物无明显促进吸收作用,甘胆酸钠和卡波姆有较弱的吸收促进作用,十二烷基硫酸钠对水飞蓟宾具有较强的促进吸收作用,而对其磷脂复合物作用较弱;聚氧乙烯氢化蓖麻油对水飞蓟宾和磷脂复合物均有较强的促进作用。结论:合理改善药物结构及选择适宜吸收促进剂能改善药物的吸收。

Objective ： To investigate effect of absorption enhancers on intestinal absorption of silybin and silybin phospholipid complex （SPC）. Method： In situ rats single pass perfusion model was uesd to investigate absorption of silybin and SPC in duodenum, jejunum, ileum and colon. Result： Silybin and SPC were absorbed in each intestinal segment, especially in jejunum and ileum, and absorption of SPC in each intestinal segments were higher than drug itself. Tween-80 had no significantly absorption enhancement effect on silybin and SPC, glycocholic acid sodium and carbomer only had silghtly promotion absorption, sodium dodecyl sulfate could greatly promote absorption of slilybin while weakly affected SPC; Cremophor~ RH40 had a strong role in promoting absorption of silybin and SPC. Conclusion： It could improve drug absorption by reasonable modifaeaiton of drug structure and selection of suitable absorption enhancers.