抗氧化蛋白Prx1在口腔黏膜白斑中的表达

Prx1 overexpression in human oral leukoplakia

目的检测抗氧化蛋白Prx1和DNA氧化损伤标记物8-OHdG在口腔黏膜白斑中的表达,探讨Prx1在口腔黏膜白斑中的作用。方法选择40例口腔黏膜白斑,包括单纯增生10例,白斑伴上皮轻度异常增生15例,白斑伴上皮中度异常增生15例,正常口腔黏膜10例。采用免疫组织化学染色方法,分别检测Prx1、8-OHdG在黏膜中的表达。结果口腔黏膜白斑伴上皮中度异常增生组Prx1和8-OHdG染色的MOD值均高于正常组、白斑单纯增生组、白斑伴上皮轻度异常增生组,且差异有统计学意义(P<0.01)。结论 Prx1与口腔黏膜白斑的发病有关,口腔黏膜白斑的发生可能与氧化损伤有关。

Objective To examine the antioxidant Prxl and 8-OHdG expression in human oral leukoplakia and to investigate their role in the pathogenesis of oral leukoplakia. Methods Expression of Prxl and 8-OHdG was detected in 10 normal oral mucusa and 40 oral leukoplakia including 10 hyperplasia , 15 oral leukoplakia with mild epithelial dysplasia and 15 oral leukoplakia with moderate epithelial dysplasia by immunohistochemistry. Results The MOD values of Prxl and 8- OHdG in the oral leukoplakia with moderate epithelial dysplasia were significantly higher than those in the normal oral mucusa, oral leukoplakia and oral leukoplakias with mild epithelial dysplasia（P 〈 0. 01 ）. Conclusion Prxl and oxidative injury may be involved in the pathogenesis of oral leukoplakia.