血清细胞因子与幽门螺杆菌相关性胃炎的关系

Relationship between CRP, TNF-α, IL-8 and Helicobacter pylori associated gastritis disease

目的研究幽门螺旋杆菌（Hp）相关性胃炎患者血清中C-反应蛋白（CRP）、肿瘤坏死因子-α（TNF—α）和白细胞介素-8（IL-8）的水平变化及与发病的关系。方法选择80例^14-尿素呼气试验阳性和病理学确诊的慢性胃炎患者，采用酶联免疫吸附法（ELISA）检测HP患者根除前后血清中CRP、TNF-α、IL-8的水平，以20例健康体检者作为对照进行分析。结果HP相关胃炎组血清CRP、TNF—α、IL-8均显著高于正常对照组（t=5．33，5．12，4．98，P〈0．05），HP根除后血清中CRP、TNF-α、IL-8水平明显下降，与根除前相比差异有统计学意义（t=4．11，4．23，3．99，P〈0．05）。结论CRP、TNF-α、IL-8与HP相关胃炎密切相关，且参与了胃黏膜损伤的病理过程。

Objective To study the change of serum levels of CRP, TNF-α and IL-8 in Helicobacter pylori （Hp）associated gastritis disease and the relationship between the serum levels of CRP, TNF-α, IL-8 and the disease process. Methods Eighty cases of Hp positive chronic gastritis were selected. ELISA were used to detect the serum levels of CRP, TNF-α and IL-8 in serum before and after Hp infection eradication. Twenty healthy subjects were used as control group. Results The serum CRP, TNF-α and IL-8 levels in patients with chronic gastritis were significanthy higher than those in control group （t = 5.33, 5. 12, 4. 98, P 〈 0. 05）. The serum levels of CRP, TNF-oL and IL-8 were obviously decreased after Hp infection eradication （t = 4. 11,4. 23, 3.99, P 〈 0. 05）. Conclusions CRP, TNF-α and IL-8 are closely associated with Hp infection, and they play a significant role in mucosal injury.