急性心肌梗死合并系统性红斑狼疮三例临床特点分析及文献复习

Clinical Characteristics of Acute Myocardial Infarction Patients Combined with System Lupus Erythematosus: Report of Three Cases and Review of Literatures

目的了解急性心肌梗死(AMI)合并系统性红斑狼疮(SLE)的临床特点和转归,以提高临床医生对其认识。方法回顾性分析2001—2011年我院住院的AMI合并SLE患者的临床资料,分析其临床和实验室指标特点。结果 3例患者中,2例男性、1例女性,AMI发病年龄轻,冠状动脉病变重、广泛弥漫,SLE病程长。2例SLE患者病情有复发,其中1例AMI时SLE活动,2例受传统冠心病危险因素影响不大。结论除传统冠心病危险因素外,SLE本身也是独立的危险因素,应加强冠心病二级预防,重视SLE的治疗。

Objective To explore the characteristics, management and outcome of acute myocardial infarction （AMI） patients combined with system lupus erythematosus （SLE） in order to improve clinical recognition for such patients. Methods Clinical data and laboratory parameters of AMI combined with SLE patients admitted to our hospital from 2001 to 2011 were retro- spectively analyzed. Results Two males and one female had AMI onset with young age and they suffered from severe and exten- sive coronary lesions with a long course. Another two cases had relapsing courses, among which one had active SLE when having AMI onset, and two weren＇t influenced much by traditional coronary heart disease risk factors. Conclusion Besides traditional coronary heart disease risk factors, SLE is an independent risk factor for coronary heart disease. Secondary prevention of coronary heart disease should be enhanced and treatment of SLE should be taken seriously.