恶性肿瘤骨转移——亚临床灶

Bone Metastasis of Malignant Tumor——Sub clinical Foci

目的 :研究恶性肿瘤病人隐匿性骨转移发生率及其性质。 方法 :对恶性肿瘤病人进行放射性核素骨显像 ,X线检查及物理检查 ,并严格定义骨显像阳性为出现放射性核素多发浓集区。对于骨显像阳性 ,X线检查及骨痛均为阴性的诊断为隐匿性骨转移 ,并进行 4年随访。 结果 :发现在所有骨显像病例中 ,亚临床骨转移发生率为 2 6 / 12 78(2 .0 % )。经随访发现 ,有 12 / 19(6 3.2 % )的病人在 4年内可出现临床可见的骨转移。 结论 :对于多发性亚临床骨转移应给予积极的治疗 ,而对于单发的亚临床骨转移应持保守态度为宜。对亚临床骨转移的研究 ,将有利于合理及时的治疗 ,有助于病人的预后。

To study the incidence and characteristics of bone metastasis in malignant tumor sub-clinical foci.Methods:The bone metastasis of malignant tumor was studied with bone scintigraphy.X ray and physical examinations.Multiple concentrating foci of radionuclide was strictly difined as positive finding in bone scintigraphy.The sub-clinical bone metastasis was diagnosed if bone scintigraphy had positive finding and both X ray examination and bone pain had negative findings.Results:It was showed that the incidence of sub-clinical bone metastasis in all bone scintigraphy patinets was 26/1278(2.0%), and 12/17(63.2%)of those patients would have bone metastasis clinically during 4 years follow-up period.Conclusion:We believed that the multiple sub-clinical foci should be treated as routine bone metastasis,while the single sub-clinical focus conservatively.It was suggested that further study of sub-clinical bone metastasis would be helpful to the rational treatment and the improvement of the prognosis of the disease.