VEGF在新疆维吾尔族胶质瘤患者肿瘤组织中表达的临床研究

The clinical research of the expression of VEGF in gUoma tissue of Uygur people in Xinjiang

目的探讨新疆维吾尔族胶质瘤患者肿瘤组织中血管内皮生长因子（VEGF）表达水平与肿瘤病理级别之间的相关性以及民族因素对胶质瘤VEGF表达水平的影响。方法运用免疫组化法检测33例维吾尔族胶质瘤患者以及61例汉族胶质瘤患者肿瘤组织中的VEGF表达水平，对其与病理级别之间的相关性和种族因素对胶质瘤肿瘤组织中VEGF表达水平的影响进行分析。结果6I例汉族胶质瘤患者肿瘤VEGF阳性率为81．97％，33例维族胶质瘤患者VEGF阳性率为60．61％，两个种族间差异有统计学意义（P〈0．05）。分别对两民族胶质瘤组织VEGF表达水平与病理级别的相关性进行统计学分析，汉族患者肿瘤VEGF表达水平与病理级别显著相关（P〈0．05）；维吾尔族患者肿瘤VEGF表达水平与病理级别无明显相关（P〉0．05）。结论胶质瘤患者肿瘤组织VEGF阳性率及其表达水平与病理级别之间的相关性均受到种族因素的影响。

Objective To investigate the correlation between the expression of tumor VEGF and pathological grade,and the influence of racial factors on tumor VEGF expression levels for glioma patients. Methods Compare and analysis the correlation between the pathological grade and VEGF levels and the racial factors on VEGF expression levels by the immunohistochemical staining on the tumor specimens of 33 Uygur and 61 Han. Results The positive rate of 61 Han gliomas pations with VEGF is 81.97% and 33 cases of the Uygur is 60.61% , there＇s clear correlation between the racial factors and the tumor VEGF levels. （P 〈 0.05）. Comparative the two groups patients separately with pathological level and tumor VEGF level, there is no clear correlation in Uygu （ P 〉 O. 05 ） and opposite in Han （ P 〈 0.05 ）. Conclusion There＇s significant effect of the racial factors on the positive of glioma＇s VEGF and the relation between the pathological grade and the expression levels.