摘要
目的:探讨F0LFOX及FOLFOX4两种化疗方案治疗Dukes B,C期直肠癌术后的临床效果及安全性。方法:选择笔者所在医院收治的54例Dukes B,C期直肠癌术后接受FOLFOX与FOLFOX4方案化疗的患者为研究对象,对比分析接受不同化疗方法的患者毒副反应情况、5年复发率及生存率。结果:两组毒副反应发生率差异无统计学意义,但F0LFOX4组Ⅲ度以上毒副反应发生率明显低于F0LFOX组(P<0.05);两组5年复发率及生存率差异无统计学意义。结论:F0LFOX4方案毒副反应相对较轻,且简便易行,值得广泛应用。
Objective: To discuss the clinical effect and security of Dukes B, C colorectal cancer postoperative patients treated by the FOLFOX and FOLFOX4 chemotherapy treatment scheme. Methods: To choose 54 cases Dukes B, C colorectal cancer postoperative patients treating with the FOLFOX and FOLFOX4 chemotherapy treatment scheme as the research object, and analyze the adverse reaction, 5 years recurrence rate and survival rate of patients treating with different chemotherapy treatment scheme. Results: There were no significant differences of adverse reaction rate between the two groups, adverse reaction rate above ]II degrees of the FOLFOX4 group was slgnificantiy lower than that of the FOLFOX group(P〈0.05). The 5 years survival rate and survival rate had no significant differences between the two groups. Conclusion: The adverse reaction rate of FOLFOX4 scheme is relatively light, and easy to use, is worth widely used.
出处
《中国医学创新》
CAS
2012年第18期8-9,共2页
Medical Innovation of China