黄元胶囊质量标准的研究

Study on Quality Standard of Huangyuan Capsules

目的建立黄元胶囊的质量标准。方法采用TLC法鉴别大黄;采用HPLC法测定大黄素、大黄酚的含量。结果 TLC斑点清晰,易于观察。大黄素和大黄酚分别在0.064～0.64μg(r=0.9999)和0.112～1.12μg(r=0.9998)线性关系良好。大黄素的平均回收率为98.28%,RSD为1.49%;大黄酚的平均回收率为99.44%,RSD为0.68%。结论本文建立的方法简便、准确、专属性强,可作为黄元胶囊的质量控制标准。

Objective To establish a quality standard of Huangyuan Capsules.Methods The radix et rhizoma rhei was identified by TLC while the content of emodin and chrysophanol was determined by HPLC.Results The spots in TLC were fairly clear and distinct as well.Emodin and chrysophanol showed a good linear relationship in the range of 0.064-0.64 μg（r=0.9999） and 0.112-1.12 μg（r=0.9998）,respectively.The average recovery of emodin was 98.18% with an RSD of 1.49%（n=6）.The average recovery of chrysophanol was 99.44% with an RSD of 0.68%（n=6）.Conclusion This method is simple,accurate and specific,which can be used for quality control of Huangyuan Capsules.