2009—2010年丙戊酸钠血药浓度监测数据分析

Data Analysis of Sodium Valproate Blood Concentration from 2009 to 2010

目的探讨丙戊酸钠血药浓度监测及临床意义。方法采用荧光偏振免疫分析法测定癫痫患者血清中丙戊酸浓度,并回顾性分析1220例次患者的血药浓度与临床疗效的相关性。结果 734(60.16%)例次在有效浓度范围内,377(30.90%)例次小于有效浓度范围,109(8.94%)例次高于有效浓度范围;不同年龄段患者的血药浓度有效治疗范围无明显差异;给药剂量与血药浓度的相关性不稳定。结论丙戊酸钠血药浓度个体差异大,因此在服药期间应适时监测血药浓度,并及时调整给药剂量,以提高临床疗效、降低不良反应。

Objective To explore the monitoring result of plasma concentration of sodium valproate and its clinical significance.Methods The valproic acid concentration in epileptic patients’ serum was measured by fluorescence polarization immunoassay.The relation between the plasma concentration of 1220 patients and the clinical efficacy was reviewed.Results The measured results of 734 patients（60.16%） fell within the effective concentration range,377 cases（30.90%） did not while 109 cases（8.94%） exceeded that range.The plasma concentration showed no significant difference within the effective therapeutic range in different age groups,and the correlation of dose and plasma concentration was not constant.Conclusion The plasma concentration of sodium valproate differs a lot between individuals,so it should be regularly monitored and the dose should be adjusted in time during medication in order to improve clinical efficacy and reduce adverse drug reactions.