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microRNA转基因小鼠在心脏发育研究中的应用

Application of MicroRNA Transgenic Mouse Model in Heart Development Research
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摘要 microRNA（miRNA）参与调控胚胎心脏的发育，在心脏形态发生、心肌细胞生长及分化过程中发挥着极其重要的作用。通过转基因技术可以实现特异miRNA在心肌组织的过表达与敲除，据此建立的心肌特异性miRNA转基因小鼠模型可以在整体水平揭示miRNA心脏方面的功能。近年，以miRNA为研究对象的心肌特异性转基因小鼠模型数量不断增加。 MicroRNAs （miRNAs） are essential for posttranscriptional gene regulation and play important roles in embryonic heart development, heart morphogenesis, myocardial cell growth and differentiation. Overexpression and knockout of the cardiac tissue-specific miRNAs by transgenic techniques enable the establishment of the cardiac-specific miRNA transgenic mouse and thus the discovery of miRNAs in cardiac function at an overall level. Recently, the number of cardiac-specif- ic miRNA transgenic mouse models are increasing and diversifying.
作者 余章斌 郭锡熔
机构地区 南京医科大学附属南京妇幼保健院儿科
出处 《医学分子生物学杂志》 CAS CSCD 2012年第2期132-135,共4页 Journal of Medical Molecular Biology
基金 国家自然科学基金（No.81070500）,南京市医学科技发展资金
关键词 微小RNAS 转基因小鼠 心脏发育 microRNA transgenic mouse heart development
分类号 R342.3 [医药卫生—基础医学]
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医学分子生物学杂志
2012年 第2期

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