抑郁情绪大鼠模型中糖水偏好实验数据的聚合分析

Depression in Rat Model Sucrose Preference Test Data Analysis of Aggregation

目的探讨抑郁情绪大鼠模型糖水偏好实验（Sucrosepreferencetest，SPT）中糖水偏好SP（Sucrosepreference，sp）系数的最佳聚合方式。方法慢性温和刺激法复制抑郁情绪大鼠模型。4周造模过程中，每隔一周采集一次大鼠的行为学数据，并对糖水偏好实验数据采用两两聚合的分析方法处理。比对不同聚合手段对模型制备信度及相关性的影响。结果①一致性系数（Kappa）结果显示，只有第3种聚合方式能得到较高的可信度（Kappa=0．611），②组内相关系数（ICC）结果表明，聚合方式中TM的可信度最高（ICC=0．910）。结论恰当的数据聚合方式可以大幅提升抑郁情绪大鼠糖水偏好实验中数据的可信度与稳定性。

Objective To explore the rat model depression sucrose preference test （Sucrose preference test, SPT） in sucrose preference value SP （Sucrose preference） the best aggregation. Methods Chronic mild stress （CMS） rat model of depression was replicated. In the four weeks of modeling process, gathering a sucrose preference test data for every other week, and the sucrose preference test data using twi-two aggregation analysis approach. Aggregation of different means than the preparation of model reliability and correlation effects. Result （1） Kappa TM showed only way to get a higher aggregate reliability （Kappa = 0.611）, （2） ICC results showed that the aggregation of TM＇s credibility highest （ICC = 0.910））. Conclusion The appropriate data aggregation can significantly improve depression in rats with sucrose preference test data credibility and stability.