摘要
随着肠道菌群与人类疾病及健康的关系研究的深入，已证实肠道菌群不仅构成黏膜屏障、参与食物消化、刺激免疫及胃肠功能发育，而且作为内化的环境因素参与肥胖、糖尿病、IBD、肿瘤等多种疾病的发生，肠道菌群与人类疾病及健康关系研究的深入对动物模型提出了新要求。无菌动物作为微生物背景最清晰的动物，可有效地对菌群、基因及其它环境因素进行控制，是研究肠道菌群对人类疾病及健康的影响的最有效的动物模型。利用无菌动物构建的悉生动物模型及菌群人源化动物（HHA动物）模型已在肠道菌群对宿主生理功能的影响、代谢性疾病发生、药物代谢等研究领域广泛应用。
Gut microbiota has been reported to involve in host physiology functions, certain pathological disorders, and drug metabolism. The gut microbiota colonization is also involved in several important development of physiological function, especially development of immune system and digestive system. As the cleanest animal associated no microorganism, germ free animal is a precondition to study the relationship between microbiota and human health state. Germ free animal, gnotobiotic animals and human flora associated animals have been widely used in studying the effect of microbiota on host development, etiological factor of metabolic disease and drug metabolism.
出处
《实验动物与比较医学》
CAS
2012年第3期250-253,258,共5页
Laboratory Animal and Comparative Medicine
基金
[基金项目】国家重点基础研究发展计划（973计划）（项目编号：2007CB513007）.
关键词
无菌动物
肠道菌群
悉生动物
HFA动物
Germ free animal
Gut microbiota
Gnotobiotic animals
Human flora associated animal
