系统性红斑狼疮microRNA的异常表达及其与DNA甲基化的相互调控

Abnormal expression of microRNAs and mutual regulation between microRNAs and DNA methylation in systemic lupus erythematosus

系统性红斑狼疮是一种复杂的慢性、全身性自身免疫性疾病，其发病机制尚不明确。近年研究表明，microRNA和DNA甲基化在内的表观遗传修饰异常可能在系统性红斑狼疮的发生发展中起作用。MicroRNA是非编码单链小RNA，已有研究提示，microRNA参与了系统性红斑狼疮的发病和疾病进展，而其与DNA甲基化的相互作用可通过调控细胞内基因表达进而影响疾病的发生发展。概述了microRNA的异常表达及其与DNA甲基化之间的相互关系在系统性红斑狼疮发病机制中的作用，旨在为系统性红斑狼疮的研究提供新的思路。

Systemic lupus erythematosus （SLE） is a complex, chronic and autoimmune disease with unclear pathogenesis. Recent studies have shown that abnormality in epigenetic modifications, including microRNAs and DNA methylation, may play an important role in the occurrence and development of SLE. It has been demonstrated that microRNAs, as a group of small non-coding single-stranded RNAs, take part in the occurrence and development of SLE, and their interaction with DNA methylation may affect the occurrence and development of SLE via regulating intracellular gene expression. The authors summarize the roles of abnormal expression of microRNAs as well as their interaction with DNA methylation in the pathogenesis of SLE, aiming to offer a new clue into the research in SLE.