摘要
目的探讨尼可地尔治疗对冠状动脉慢血流患者冠状动脉贮备功能的影响。方法选择冠状动脉造影正常但存在冠状动脉慢血流的患者44例,所有患者随机分为治疗组和对照组,对照组(20例)予常规治疗,治疗组(24例)在常规治疗基础上加用尼可地尔5 mg,每天3次,治疗期为6个月。利用腺苷负荷超声记录左前降支远端血流频谱评价冠状动脉储备功能。结果经过6个月尼可地尔的治疗后,治疗组静息冠状动脉血流速度较对照组和治疗前无明显差别(26.37±5.39 cm/s比24.72±4.35 cm/s,26.37±5.39 cm/s比24.61±6.18 cm/s,均P>0.05),最大冠状动脉扩张状态较对照组和治疗前明显增加(73.69±9.84 cm/s比55.97±7.62 cm/s,73.69±9.84cm/s比51.29±9.72 cm/s,均P<0.05),而冠状动脉血流储备功能较对照组和治疗前明显增加(2.79±0.53比1.99±0.47,2.79±0.53比2.08±0.44,均P<0.05)。结论长期尼可地尔治疗可以有效改善冠状动脉慢血流患者冠状动脉贮备功能。
Aim To investigate the impact of nicorandil on coronary flow reserve（CFR） in patients with slow coronary flow.Methods A total of 44 patients with coronary slow flow but normal coronary angiography were included in this study,patients were divided into nicorandil group（5 mg/d for 6 months,n24） and control group（n20）,Doppler coronary flow velocity and Doppler reserve measurement of distal left anterior descending were recorded at rest and adenosine measurement of distal left anterior descending were recorded at rest and adenosine infusion induced hyperemia state,CFR was calculated by the ratio of maximal hyperemia and baseline peak diastolic coronary flow velocity（HCFV and BCFV） before and after nicorandil treatment.Results 6 months later,compared with control group and nicorandil group before treatment,6 months nicorandil treatment was associated with no difference of BCFV（26.37±5.39 cm/s vs 24.72±4.35 cm/s,P0.05;26.37±5.39 cm/s vs 24.61±6.18 cm/s,P0.05）,increased HCFV（73.69±9.84 cm/s vs 55.97±7.62 cm/s,P0.05;73.69±9.84 cm/s vs 51.29±9.72 cm/s,P0.05）,and increased CFR（2.79±0.53 vs 1.99±0.47,P0.05;2.79±0.53 vs 2.08±0.44,P0.05）.Conclusion Coronary flow reserve could be significantly improved by nicorandil therapy in patients with coronary slow flow.
出处
《中国动脉硬化杂志》
CAS
CSCD
北大核心
2012年第7期631-634,共4页
Chinese Journal of Arteriosclerosis
