水杨酸甲酯乳糖苷含量测定方法的研究

Determination methods for the content of methyl salicylate-2-O-β-Dgalactopyranoside (1-4)-β-D-glucopyranoside

水杨酸甲酯乳糖苷（methyl salicylate-2-O-β-D-galactopyranoside（1-4）-β-D-glucopyranoside,MSG,C20H28O13）为一个新化合物,结构见图1,具有消炎、清热、镇痛的作用。MSG因其结构的特异性,与其他非甾体抗炎药有着不同的体内代谢方式,因而大大降低了该类药物的胃肠道不良反应;且其在体内维持时间长、与其他非甾体抗炎药比较发挥作用时间更长。作者根据其结构,分别使用化学分析法与仪器分析法对其含量测定的方法进行了研究。

The paper is to report the establishment of three methods for determination of methyl salicylate- 2-O-β-D-galactopyranoside （1-4）-β-D-glucopyranoside （MSG） by HPLC, UV or potentiometric titration. The results determined by the three methods turned out to be of no significant difference （P〉0.05）. The method was chosen according to MSG difference test demands.