乳腺癌中PTEN、Rb、C-myc的异常表达及其临床意义

Aberrant expression of PTEN,Rb and C-myc in breast cancer and its clinical significance

目的探讨PTEN、Rb、C-myc蛋白异常表达在乳腺癌发生、发展中的作用及其临床意义。方法应用免疫组织化学S-P法检测150例乳腺癌和30例乳腺良性增生性病变组织中PTEN、Rb、C-myc蛋白的表达;结合临床病理指标进行分析。结果乳腺癌组织中PTEN、Rb、C-myc蛋白表达与良性增生性病变组织有显著差异(P<0.05)。PTEN蛋白的失表达与淋巴结转移、雌激素受体(ER)失表达有关(P<0.05)。Rb蛋白在乳腺癌Ⅲ级中失表达率较高,但无统计学差异(P>0.05)。C-myc蛋白的过表达与组织学分级、淋巴结转移及病理类型有关(P<0.05)。PTEN蛋白失表达与Rb蛋白失表达呈正相关,与C-myc过表达呈负相关(P<0.05)。结论 PTEN、Rb、C-myc共同参与了乳腺癌的发生发展,对乳腺癌的预后判断有重要的参考价值。

Objective To investigate the roles of aberrant expressions of PTEN,Rb and C-myc in development of breast cancer and its clinical significance.Methods Immunohistochemical（S-P method） was used for detecting proteins of PTEN,Rb and C-myc in 150 cases of breast cancer and 30 cases of benign proliferative lesions.The outcome was analyzed together with their relation to clinical pathological parameters.Results There were significant differences in expressions of PTEN,Rb and C-myc proteins between breast cancer and benign proliferative lesions（P0.05）.Loss of expression of PTEN protein was related with lymph nodes metastasis and the loss of expression of ER（P0.05）.The loss of expression rate of Rb protein was higher in breast cancer grade Ⅲ,but there was no statistical difference（P0.05）.Overexpression of C-myc protein was related with histological grade,lymph node metastasis and pathological type（P0.05）.There was a positive correlation between PTEN and Rb,a negative correlation between PTEN and C-myc（P0.05）.Conclusions PTEN,Rb and C-myc co-participate in the development of breast cancer.They have important reference value to judge the prognosis of breast cancer.