妊娠中期母体血清游离β-人绒毛膜促性腺激素水平异常与不良妊娠结局的相关性

The correlation of the abnormal level of maternal serum-free IS-human chorionic gonadotropin during second-trimester pregnancy and adverse pregnancy outcome

目的研究妊娠中期母体血清游离β-人绒毛膜促性腺激素（β-hCG）水平异常与不良妊娠结局的相关性。方法妊娠中期孕妇209例，抽血检测血清β-hCG，随访至分娩。观察孕妇血清β-hCG水平异常与不良妊娠结局的相关性。结果209例孕妇中血清β-hCG水平超标105例（超标组），为（84．9±11．6）kU／L；血清β-hCG水平正常104例（正常组），为（18．6±1．3）kU／L。其中超标组妊娠期高血压疾病、早产、胎膜早破、新生儿出生后窒息的发生率均高于正常组[14．3％（15／105）比0、18．1％（19／105）比2．9％（3／104）、11．4％（12／105）比0、29．5％（31／105）比0，P〈0．05]。结论妊娠中期孕妇血清13．hCG水平异常可反映胎盘功能，是发生不良妊娠结局的信号，测定血清β-hCG水平有利于较早预防不良妊娠结局。

Objective To study the correlation of the abnormal level of maternal serum-free β-human chorionic gonadotropin （ β-hCG ） during second-trimester pregnancy and adverse pregnancy outcome. Methods Two hundred and nine pregnant women in second-trimester pregnancy were detected serum β-hCG and followed up till delivery. The correlation of the abnormal level of serum β-hCG and adverse pregnancy outcome were observed. Results In 209 pregnant women,the level of serum β-hCG of 105 cases were over standard [（84.9 ± 11.6） kU/L] （over standard group）,while the level of the rest 104 cases were （18.6 ± 1.3） kU/L within normal range （normal group）. The incidence rate of gestational hypertension, premature delivery, premature rupture of membranes and suffocation of new born infants in over standard group were all higher than those in normal group [ 14.3% （ 15/105 ） vs. 0,18.1% （ 19/105 ） vs. 2.9% （3/104）,11.4%（12/105） vs. 0,29.5%（31/105） vs. 0,P〈0.05]. Conclusions The abnormality of serum -hCG of women in second-trimester pregnancy can reflect the placenta dysfunction and it is a signal of adverse pregnancy outcome. Therefore,detecting the level of serum β-hCG is useful for preventing adverse pregnancy outcome.