穴位注射神经生长因子治疗Ramsay Hunt综合征临床观察

Effect of Acupoint Injection with Nerve Growth Factor on Ramsay Hunt Syndrome

目的观察电针结合穴位注射鼠神经生长因子治疗Ramsay Hunt综合征的临床疗效及后遗神经痛发生率。方法 65例患者按就诊单双日分为试验组(n=33)和对照组(n=32),两组患者就诊时给予抗病毒及糖皮质激素治疗,并即时电针治疗,电针取穴采用阳白-旁阳白(阳白外侧1.5寸)、承泣-瞳子髎、颊车-牵正、颧髎-地仓、迎香-上迎香5组;试验组在此基础上加用穴位注射鼠神经生长因子,穴位注射取穴完骨、阳白、颧髎、地仓。每治疗5次休息2 d,10次为1个疗程,治疗2个疗程后,比较治疗效果和3个月后神经痛发生率。结果试验组总有效率(93.9%)明显高于对照组(71.9%)(P<0.01)。3个月后随访62例,丢失3例,随访率为95.4%。试验组后遗神经痛发生率(6.3%)明显低于对照组(26.7%)(P<0.01)。结论电针结合穴位注射鼠神经生长因子治疗RamsayHunt综合征可提高疗效,降低后遗神经痛发生率。

Objective To observe the clinical effect and the incidence of neuralgia of acupoint injection with nerve growth factor on Ramsay Hunt syndrome.Methods 65 patients with Ramsay Hunt syndrome were divided into treatment group（n=33） and control group（n= 32）.All the patients were treated with the anti-virus and glucocorticoid medicine,and were acupunctured at the similar points with electroacupuncture with the disperse dense wave.The treatment group was injected with mouse nerve growth factor at the acupoints.2 days off every 5 times,10 times as a course for 2 courses.The treatment effect and the incidence of sequelae neuralgia after 3 months were compared.Results The total effective rate of treatment group（93.9%） was significantly higher than control group（71.9%）（P0.01）.The incidence of sequelae neuralgia of the treatment group（6.3%） was significantly lower than the control group（26.7%）（P0.01）.Conclusion Acupoint injection of mouse nerve growth factor can improve the efficacy and reduce the incidence rate of sequelae neuralgia in patients with Ramsay Hunt syndrome.