无功能垂体腺瘤药物治疗的研究进展

Advances in Medical Treatment of Clinically Nonfunctioning Pituitary Adenomas

无功能垂体腺瘤是垂体腺瘤中最常见的类型,由于缺乏临床症状和激素高分泌状态,一般发现较晚。虽然无功能垂体腺瘤是良性肿瘤,但由于诊断时肿瘤往往已侵犯周围组织,手术很难全部切除,且术后易复发。近年来,药物治疗垂体腺瘤的研究取得了飞速进展,药物能使部分无功能垂体腺瘤患者肿瘤体积缩小,临床症状改善。

Clinically nonfunctioning pituitary adenomas are the most common types among pituitary adenomas. These tumors are usually diagnosed in their later stages due to the absence of clinical symptoms and detectable hormonal hypersecretion. Although these tumors are benign, they are hard to be completely removed during neurosurgery due to the massive invasion into the surrounding tissues at diagnosis. Furthermore, relapse is common. In recent years, medical treatment of pituitary adenomas has witnessed a rapid development. New medications have shown certain effectiveness in reducing the tumor size and improving the clinical symptoms.