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RNA聚合酶ω亚基的研究进展 被引量：2

Research progress on ω subunit of RNA polymerase
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摘要 阐述了ω(Omega)亚基是细菌RNA聚合酶(RNA polymerase,RNAP)的核心酶中最小的1个亚基。其在结构上主要是起到保护β′亚基、帮助β′亚基折叠并协助RNA聚合酶组装等作用。探讨了ω亚基在链霉菌属、分支杆菌属以及十字花科黑腐病菌等细菌中的功能。阐述了ω亚基对抗生素的合成、形态变异以及生物膜形成的影响,参与了细胞内鸟苷四磷酸(ppGpp)水平的调节。 ω subunit was the smallest subunit of bacterial RNA polymerase（RNAP） core enzyme with function of protecting β subunit and helping the assembly of the RNA polymerase.Function of ω in Streptomyces spp.,Mycobacterium spp.and Xanthomonas campestris and the effect on antibiotics synthesis,morphological differentiation,bio-film formation and regulation of level of ppGpp in cell were discussed.
作者 魏亚蕊 吴小刚 伊卫东 周洪友
机构地区 内蒙古农业大学农学院 中国农业大学农学与生物技术学院
出处 《中国植保导刊》 北大核心 2012年第6期11-15,共5页 China Plant Protection
基金 国家863计划(2011AA-10A210) 国家自然科学基金(30860166) 内蒙古自然基金(2010MS0306)
关键词 RNA聚合酶 ω亚基 抗生素 生物膜 形态变异 PPGPP RNA polymerase ω subunit antibiotics biofilm morphological differentiation ppGpp
分类号 Q753 [生物学—分子生物学]
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参考文献22

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二级参考文献22

  • 1Burgess R R.Separation and characterization of the subunits of ribonucleic acid polymerase[J].The Journal of Biological Chemistry,1969,244:6168-6176.
  • 2Mathew R,Chatterji D.The evolving story of the omega subunit of bacterial RNA polymerase[J].Trends in Microbiology,2006,14:450-455.
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  • 6Ghosh P,Ishihama A,Chatterji D.Escherichia coil RNA polymerase subunit omega and its N-terminal domain bind full-length β' to facilitate incorporation into the α2β subassembly[J].European Journal of Biochemistry,2001,268:4621-4627.
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  • 8Kojima I,Kasuga K,Kobayashi M,Fukasawa A,Mizuno S,Arisawa A,Akagawa H.The rpoZ gene,encoding the RNA polymerase omega subunit,is required for antibiotic production and morphological differentiation in Streptomyces kasugaensis[J].Journal of Bacteriology,2002,184:6417-6423.
  • 9Mathew R,Mukherjee R,Balachandar R,Chatterji D.Deletion of the gene rpoZ,encoding the ω subunit of RNA polymerase,results in pleiotropic surface-related phenotypes in Mycobacterium smegmatis[J].Microbiology,2006,152:1741-1750.
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中国植保导刊
2012年 第6期

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