26例小剂量干扰素联合阿糖胞苷治疗慢性粒细胞白血病的临床分析

Clinical Analysis of 26 Cases of Small-dose Interferon in Combination with Cytarabine to Treat Chronic Myelogenous Leukemia

目的探讨小剂量干扰素联合阿糖胞苷治疗慢性粒细胞白血病的临床疗效。方法将26例慢性粒细胞白血病分为治疗组和对照组,两组均以羟基脲(Hu)治疗为基础,当患者外周血白细胞<20.0×109/L时,对照组采用小剂量干扰素单药治疗,治疗组在对照组的基础上采用小剂量阿糖胞苷治疗,比较两组的治疗效果。结果治疗组的血液学缓解总有效率、遗传学缓解总有效率分别为93.3%、66.7%显著高于对照组的72.7%、45.5%(P<0.05)。治疗组达到血液学完全缓解率、细胞遗传学缓解的平均时间显著短于对照组(P<0.05)。治疗组与对照组的不良反应发生情况无显著性差异(P>0.05)。结论小剂量干扰素联合阿糖胞苷治疗慢性粒细胞白血病可提高治疗效果。

Objective To investigate the small doses of interferon combined with cytarabine for treatment of chronic granulocytic leukemia clinical curative effect.Methods 26 cases of chronic granulocytic leukemia is divided into treatment group and control group,two groups were to hydroxyurea（Hu） treatment for the foundation,when peripheral white blood cells of patients with 20×109/L,control group with small dose interferon monotherapy,the treatment group in the control group based on the use of small dose cytosine arabinoside treatment,compared with two group of treatment effect.Results The treatment group of haematological remission total efficiency is 93.3% higher than the control group（P 0.05）72.7%.The treatment group of genetics to alleviate the total efficiency is 66.7% higher than the control group（P 0.05）45.5%.The treatment group achieved hematological complete remission rate,cytogenetic remission and the average time was significantly shorter than that in control group（P0.05）.The treatment group and the control group the incidence of the adverse reactions of no significant difference（P0.05）.Conclusion Effects of small doses of interferon combined with cytarabine can improve the therapeutic effect.