乳酶生片联合达克宁栓治疗复发性念珠菌性阴道炎疗效观察

Lactasin tablet combined with miconazolIe suppository for recurrent vulvovaginal candidiasis

目的观察乳酶生片联合达克宁栓治疗复发性念珠菌性阴道炎疗效。方法300例复发性念珠菌性阴道炎患者随机、单盲分为治疗组150例和对照组150例，对照组采用达克宁栓200mg，阴道上药，每晚一次，共用7天。治疗组在对照组的基础上加用乳酶生片0．6g，每晚一次，共用7-10天。两组用药均每月重复一次，连用3个月。分别于治疗前，治疗后1个月、2个月、3个月进行疗效观察，比较复发情况。结果治疗组总有效率为94．7％，治疗3个月后复发率为5．97％；对照组总有效率为85．3％，治疗3个月后复发率为19．04％，治疗组疗效明显优于对照组（P〈0．01），治疗组各症状复发明显少于对照组（P〈0．05）且治疗组复发率明显低于对照组（P〈0．01）。结论乳酶生片与达克宁栓合用治疗复发性念珠菌性阴道炎效果良好，可明显减少复发。

Objective To observe lactasin tablet combined with miconazole suppository in the treatment of recurrent vulvovaginal candidiasis. Methods 300 patients with recurrent vulvovaginal candidiasis were randomly and blindly divided into study group and control group, 150 for each group. The control group received miconazole vaginal suppository of 200 mg once per night for 7 to 10 days, while the study group received lactasin tablet of 600 mg per night for 7 to 10 days in addition to therapy with vaginal suppository. The same therapy was applied twice monthly in the same group for three months. The efficacies were observed in both groups one, two, and three months after treatment; the recurrence rates were compared. Results The study group was superior to the control group in the efficacy （ 94.7% vs. 85.3% for the total effectiveness rate, 5.97% vs. 19.04% for the recurrence rate 3 months after treatment; P〈 0.01 ）. The rate of symptom recurrence was significantly lower in the study group than in the control group （ P 〈 0.05 ）, and so was the recurrence rate （ P 〈 0.01 ）. Conclusions Lactasin tablet combined with miconazole suppository for recurrent vul- vovaginal candidiasis is efficacious and can significantly reduce recurrence.