防治新生儿缺氧缺血性脑病的最佳时机研究

Study on best timing of preventing and treating HIE

目的探讨防治新生儿缺氧缺血性脑病（HIE）的最佳治疗时机。方法回顾性分析120例HIE患儿的临床资料，按照治疗时间分为对照组和3个实验亚组，对其NBNA、MDI、PDI的评分进行分析。结果与对照组比较，3个实验亚组患儿的胎龄、体重均明显降低（P〈0．01）实验I组孕母年龄、NBNA与对照组相比，差异有显著性（P〈0．05P3个实验亚组出院后3个月、6个月MDI统计学评分均明显增加（P〈0．01P实验I组出院后3个月、6个月PDI得分较其他三组明显增加（P〈0．05）。结论对出生后6h内的患儿进行治疗，不论是神经行为方面，还是智力和行为，预后都较其他时间段治疗改善颇多。

Objective To discuss the best timing of therapy for neonate hypoxic ischemic encephalopathy （HIE）. Methods Retrospective study on 120 inpatients with moderate HIE in the hospital was carried out. They were assigned into the control group and three experimental groups, for evaluation of NBNA, MDI and PDI. Results Compared with control group, the gestational age and weight in three experimental group were significantly reduced （P〈0.01）; the MDI statistics scores in 3 and 6 months after discharge of three experiment groups were significantly increased （P〈0.01）; the PDI scores of the experiment group I 3 and 6 months after discharge increased more obviously than the score of the other three groups （P〈0.05）. Conclusion The prognosis of HIE therapy should be initiated within six hours for better improving prognosis, nervous and mental factors for the neonates, which is much better than those after six hours.