奥美拉唑联合善宁治疗肝硬化合并上消化道出血的临床研究

Clinical research on omeprazole combined with sandostatin the treatment for hemorrhage of upper digestive tract with hepatic cirrhosis

目的观察奥美拉唑联合善宁治疗肝硬化合并上消化道出血的临床疗效。方法将我院从2006年1月至2011年9月收治的159例肝硬化合并上消化道出血病患随机均分为A、B、cj组，A组为治疗组采用奥美拉唑40mg／日（首剂80mg，后以8mg／h维持5h）联合善宁0．1mg／日（维持剂量0．025mgh）治疗，B、C组为对照组，分别单用奥美拉唑和善宁治疗，三组均给予补静脉充血容量，8mg去甲肾上腺素合并100ml冰NaCl溶液分次口服，持续1～5天。观察记录各组补液量、止血时问、便血持续时间及不良反应。结果A组补液量、止血时间和便血持续时间均低于B、C组，疗效明显优于B、C两组，差异有显著性（P〈0．05）。结论奥美拉唑联合善宁治疗肝硬化合并上消化道出血效果好，止血快而有效，无明显不良反应。

Objective To elevate the clinical curative effects of omeprazole combined with sandostatin the treatment for hemorrhage of upper digestive tract with hepatic cirrhosis. Methods 159 cases of hemorrhage of upper digestive tract with hepatic cirrhosis were randomly divided into 3 groups, with 53 cases in each group. Group A was treated with omeprazole 40 mg/d i.v. combined with sandostatin O. 1 mg/d; group B got omeprazole alone; group C had sandostatin alone. All of them got additional vein hyperemia volume, and 8 mg norepinephrine combined with 100 ml NaCl were taken through mouth by a few time. The treatment lasted for 1 - 5 days.Results In group A, the volume of fluid replacement, the hemostasis, and the time of hematochezia lasting were better than those of group B and C, so as the clinical curative effect with statistical significant difference （P〈0.05）. Conclusion The clinical curative effect of omeprazole combined with sandostatin the treatment for hemorrhage of upper digestive tract with hepatic cirrhosi is significantly effective, for its quick effectiveness, without any obvious adverse reactions.