摘要
磷脂酰肌醇3-激酶(PI3K)/Akt信号通路是参与多重生命活动的关键的信号通路,参与调节细胞的分裂、分化、凋亡等活动。PI3K/Akt信号通路与胰岛素抵抗(insulin resistance,IR)相关疾病如Ⅱ型糖尿病、心血管疾病、肥胖等关系密切。对PI3K/Akt通路的深入研究将为胰岛素抵抗相关疾病的防治提供新思路。
Phosphatidyl inositol 3-kinase （PI3K）/Akt signaling pathway is the key signal transduction pathway in many vital movements, such as cell cleavage, differentiation, and apoptosis, etc. PI3K/Akt signaling pathway has a close relationship with insulin resistance （IR） related diseases, such as type 2 diabetes mellitus, cardiovascular diseases, and obesity, etc. Profound research on PI3K/Akt signaling pathway will supply new strategy on the prevention and treatment of insulin resistance related diseases.
出处
《国外医学（医学地理分册）》
CAS
2012年第2期127-131,共5页
Foreign Medical Sciences：Section of Medgeography
基金
国家自然科学青年基金资助项目(No.30901808)
陕西省科技统筹创新工程计划资助项目(No.2011KTCL03-20)
