IL-6基因多态性与脑出血的相关性研究

Study on Correlation Between Interleukin-6 Gene Polymorphism and Cerebral Hemorrhage

目的分析IL-6基因-634位点C/G替换单核苷酸多态性与脑出血的关系。方法采用PCR和RFLP方法检测596例脑出血及335例正常对照者IL-6基因-634位点多态性。结果湖南汉族人群中,IL-6基因-634位点存在GG、GC、CC基因型,其不同基因型频率及等位基因频率在脑出血组和对照组间差异无统计学意义(P>0.05)。结论中国湖南汉族人群中,IL-6-634C/G基因多态性可能与脑出血的发病无关。

Objective To analyze the correlation between IL-6-634C/G gene polymorphism and cerebral hemorrhage（CH）.Methods PCR and RFLP were used to detect IL-6-634C/G polymorphism in 596 CH patients and 335 healthy controls.Results IL-6-634C/G had GG,GC and CC genotypes in Hunan Hans.There was no statistically significant difference in the genotypes and alleles frequencies between CH patients and the controls（P〈0.05）.Conclusions There may be no relationship between the IL-6-634C/G gene polymorphism and cerebral hemorrhage in the Hunan Hans population.