2型糖尿病并高尿酸血症相关危险因素分析

Analysis on Correlated Risk Factors for Type 2 Diabetes Mellitus Complicated with Hyperuricemia

目的探讨血尿酸(UA)及相关指标在2型糖尿病并高尿酸血症病情进展中的临床意义。方法以56例2型糖尿病并高尿酸血症和60例2型糖尿病正常尿酸患者为研究对象,测量两组患者的身高、体重、腰围、臀围、血压,检测血尿酸(UA)、血脂(TC、TG、HDL-C、LDL-C)、糖化血红蛋白(HbA1c)、C肽(CP)水平,比较两组血尿酸水平,并分析血尿酸水平与其他指标的关系。结果 2型糖尿病并高尿酸血症组体重指数(BMI)、腰臀比(WHR)、甘油三酯(TG)、糖化血红蛋白(HbA1c)、C-肽(CP)明显高于正常尿酸组(P<0.05),冠心病、高血压病发病率明显高于正常尿酸组(P<0.05),而高密度脂蛋白(HDL-C)低于正常尿酸组(P<0.05)。结论 2型糖尿病并高尿酸血症与肥胖、脂代谢紊乱、胰岛素抵抗、代谢综合征、冠心病、高血压病密切相关,应积极治疗。

Objective To explore the clinical significance of serum uric acid and the related indicators in the progression of type 2 diabetes mellitus complicated by hyperuricemia.Methods Fifty-six type 2 diabetic patients with hyperuricemia and 60 type 2 diabetic patients with normal uric acid were served as the research objects.All patients＇ height,weight,waist circumference,hip circumference and blood pressure were measured,the levels of uric acid（UA）,blood lipids（TC,TG,HDL-C and LDL-C）,glycated hemoglobin（HbA1c） and C-peptide（CP） were also determined.The levels of serum uric acid were compared between the two groups,and the relationship between the level of uric acid and other indicators was analyzed.Results Body mass index（BMI）,waist to hip ratio（WHR）,the levels of TG,HbA1c and CP of type 2 diabetic patients with hyperuricemia were significantly higher than those of type 2 diabetic patients with normal uric acid（P〈0.05）.The incidence rates of coronary heart disease and hypertension in type 2 diabetic patients with hyperuricemia were significantly higher than those of type 2 diabetic patients with normal uric acid（P〈0.05）,while the level of HDL-C in type 2 diabetic patients with hyperuricemia was lower than that of type 2 diabetic patients with normal uric acid（P〈0.05）.Conclusion Type 2 diabetic patients complicated with hyperuricemia is closely related to obesity,lipid metabolism disorder,insulin resistance,metabolic syndrome,coronary heart disease and hypertension,which should be treated actively.