高同型半胱氨酸与脑梗死再发的相关性研究

Correlation between serum homocysteine and recurrence rate of cerebral infarction

目的探讨补充叶酸、维生素B6降低同型半胱氨酸能否降低脑梗死的再发。方法将163例入选患者随机分为研究组(服用叶酸、维生素B6)及对照组,随访1年,比较服药前后同型半胱氨酸水平及脑梗死复发率。结果随访1年,151例患者完成研究,35例患者在1年内再发脑梗死。研究组同型半胱氨酸水平较对照组下降(P<0.05),两组间脑梗死再发率差异无统计学意义。结论补充叶酸、维生素B6有助于降低同型半胱氨酸水平,但并未降低脑梗死再发率。

Objective To investigate the clinical therapeutic effect of folate and Vitamin B6 on serum homocysteine and recurrence rate of cerebral infarction. Methods One hundred and sixty-five cases were randomized to experimental group （supplement with folate and Vitamin B6 ） and control group. Homocysteine level and recurrence rate of cerebral infarction were compared after 1 year. Results Serum homocysteine level of experimental group was higher than that of control group after one year follow-up. Among 151cases,35 recrudesce （23.18%）, 14 in experimental group,21 in control group. There was no statistical difference between the two groups. Conclusion Folic acid and vitamin B6 can help to reduce serum homoeysteine levels,but not to reduce the recurrence rate of cerebral infarction.