摘要
目的观察黄连素对实验性2型糖尿病大鼠血清、肾脏中黄嘌呤氧化酶(XOD)活性的影响及肾脏组织学改变。方法采用小剂量链脲佐菌素加高糖高脂饲料喂养的方法建立Wistar大鼠2型糖尿病模型,成模后给予黄连素0.1g.kg-1.d-1灌胃治疗8周,检测大鼠空腹血糖(FPG)的变化,血清和肾脏中黄嘌呤氧化酶(XOD)活性的变化,观察肾脏组织学改变。结果与糖尿病组相比,黄连素治疗组血清和肾组织黄嘌呤氧化酶(XOD)活性明显降低(P<0.01)。黄连素组大鼠肾脏组织仅见内皮细胞数目稍有增加,较糖尿病组大鼠有所改善。结论黄连素可降低大鼠体内黄嘌呤氧化酶活性、延缓DM肾脏的发生和发展。
Objective To investigate the effects of berberine on the activity of XOD in the serum and renal tissue of type 2 diabetes rats. Methods The model of type 2 diabetic rats was established by the injection of a small -dose streptozotocin combined with high glucose and fat feeding. The rats model was treated with berberine （0.1 g · kg^-1 · d^-1 ）. After 8 weeks,We detected XOD activity in the serum and kidney. Results Compared to diabetic rats, the activity of the XOD in the serum and renal tissue of rats treated with berberine decreased obviously, P 〈 0.01 ;Through pathological observation, the number of endothelial cells in berberine rats increased slightly, better than that in the rats with diabetes. Conclusions Berberine could reduce xanthine oxidase activity in vivo and delay the occurrence and development of diabetic kidney disease.
出处
《中国临床保健杂志》
CAS
2012年第3期280-282,I0005,共4页
Chinese Journal of Clinical Healthcare
