雷奈酸锶的合成

Synthesis of strontium ranelate

目的研究雷奈酸锶的化学合成。方法以无水柠檬酸为起始原料,经脱羧、酯化、环合、烷基化、水解和成盐等多步反应生成最终产物雷奈酸锶。结果雷奈酸锶的结构经IR1、H-NMR1、3C-NMR得到证实,总产率为41.4%。结论本合成路线操作简单,成本低,纯度高,适合工业化生产。

Objective To study the synthesis of strontium ranelate. Methods The strontium ranelate was synthesized from citric acid by decarboxylation, esterification, cyclization, alkylation, hydrolyzation and then salt formation. Results The structure of strontium ranelate was confirmed by IR, ^1 H - NMR,^13 C - NMR and the total yield was approximately 41.4%. Conclusion This synthesis route was simple with low cost and high purity, and it was suitable for industrial production.