绝经后女性2型糖尿病患者骨密度影响因素的因子分析

The analysis of influential factors to bone mineral density in postmenopausal women with type 2 diabetes

目的首次利用因子分析法对绝经后女性2型糖尿病(T2DM)患者骨密度(BMD)的有关因素进行分析,并重新评价BMD的影响因素。方法①收集416例绝经后T2DM患者的临床、生化和特殊检查资料作回顾性分析,采用SPSS18.0进行因子分析,提取公因子并计算因子得分。②按BMD分为正常骨密度、低骨量、骨质疏松3组,比较因子得分。结果①通过因子分析从原始指标中提取出3个公因子,分别代表体重指数和胰岛素抵抗因子、增龄和肾功能因子、脂代谢因子。②3组间3个公因子的得分存在显著性差异。结论影响绝经后女性T2DM患者BMD的3大主要因子是体重指数和胰岛素抵抗因子,增龄和肾功能因子,以及脂代谢因子。

Objective To analyze the influential factors of bone mineral density （BMD） in postmenopausal women with type 2 diabetes （T2DM） and to revalue the influential factors for BMD. Methods 1） The clinical, biochemical, and special data of 416 postmenopausal women with T2DM were collected. Factor analysis was performed using SPSS 18.0. The common factors were extracted and the score of factors were calculated. 2） The patients were divided into 3 groups： the normal BMD, osteopenia, and osteoporosis group, according to BMD. The scores of factors were compared. Results 1 ） Three common factors were extracted from the original factors, representing BMI, insulin resistance factor, the aging and renal function factor, and the lipid metabolic factor, respectively. 2） The score of the three factors among three groups had significant difference. Conclusion Our research shows that main BMD- related factors in postmenopausal women with type 2 diabetes are BMI, insulin resistance factor, aging and renal function factor, and the lipid metabolic factor.