摘要
作为转化生长因子β(TGF-β)超家族成员之一,生长分化因子9(GDF-9)被认为是卵泡生长发育和卵巢功能重要的调节因子,其通过多种途径调控优势卵泡的形成与卵母细胞的成熟。多囊卵巢综合征(PCOS)和卵巢功能早衰(POF)是育龄期妇女常见的生殖内分泌疾病,目前尚无有效的治疗方法。综述GDF-9的基因结构、功能、作用机制,及其与PCOS、POF相关性研究的最新进展。
As a member of transforming growth factor-β superfamily,growth differentiation factor-9（GDF-9） is an important regulatory factor on development and functions of follicles.GDF-9 regulates the formation of dominant follicle and process of oocyte maturation.Polycystic ovary syndrome（PCOS） and premature ovarian failure（POF） are both common reproductive endocrine diseases in women of child-bearing age,but there is no effective treatment so far.This article summarizes structure function and mechanism of action of GDF-9 gene.In addition,the relationship between GDF-9 and ovary diseases is reviewed.
出处
《国际妇产科学杂志》
CAS
2012年第3期231-234,共4页
Journal of International Obstetrics and Gynecology
基金
国家重点基础研究发展计划(973)(2010CB945103)
关键词
转化生长因子Β
多囊卵巢综合征
卵巢功能早衰
卵母细胞
基因
Transforming growth factor beta
Polycystic ovary syndrome
Ovarian failure,premature
Oocytes
Genes
