卵巢外腹膜浆液性乳头状癌研究进展

Advances in the Study of Extraovarian Peritoneal Serous Papillary Carcinoma

卵巢外腹膜浆液性乳头状癌是原发于腹膜,光镜下组织学形态同卵巢浆液性乳头状癌,而卵巢本身正常或仅浅表受累的一种恶性肿瘤,其临床表现主要为腹胀、腹痛和腹围增大等非特异性消化道症状,极易误诊为晚期卵巢癌,诊断时必须综合考虑术中情况和术后病理。该病的治疗原则以手术为主,不能彻底切除者行肿瘤细胞减灭术,术后辅以铂类为基础的联合化疗。随着对该病认识的加深及其临床诊治水平的提高,相关的病例报道也日渐增多。对近年来有关卵巢外腹膜浆液性乳头状癌的临床表现、诊断以及治疗的研究进展做一综述。

Extraovarian peritoneal serous papillary carcinoma is a kind of malignancy with its primary site in the peritoneum.The histological and cytological characteristics of the tumor resemble that of the ovarian papillary serous carcinoma.Its nidus is diffused in the perineum,but absent from the ovary or just superficially involved.The clinical manifestations of the patient are mainly non-specific symptoms of gastrointestinal tract,like the presentation of ovarian cancer in late stage.The definite diagnosis of extraovarian peritoneal serous papillary carcinoma is based on the pathologic manifestation and the events found in the surgery.The principle of treatment consists of cytoreductive surgery followed by cisplatin-based combined chemotherapy.In this review,we summarized the clinical manifestation,diagnosis and therapy of extraovarian peritoneal serous papillary carcinoma,to provide more evidence for future clinical application.