sFlt-1及PLGF与子痫前期发病的关系

sFlt-1,PLGF and Their Role in Pathogensis and Prediction of Preeclampsia

可溶性血管内皮生长因子受体1(sFlt-1)与Flt-1均属于血管内皮生长因子受体(VEGFR),其与Flt-1竞争结合VEGF,完全阻断VEGF的生物学活性,引起血管生成障碍并影响血管壁的完整性和通透性。胎盘生长因子(PLGF)是VEGF家族成员之一,PLGF与Flt-1受体结合时,发挥促血管生成和促绒毛滋养细胞增殖、浸润的效应,而这些生物学功能均可被sFlt-1阻断,且sFlt-1对PLGF具有强效的拮抗作用,调节PLGF的功能。在子痫前期妊娠妇女血清中sFlt-1的水平升高,早于疾病的发生。子痫前期患者血浆中PLGF的水平降低。sFlt-1在子痫前期发生发展过程中的作用可能与磷酯酰肌醇3激酶/蛋白激酶B(PI3K/Akt)信号转导通路有关。联合测定妊娠妇女血PLGF、sFlt-1预测子痫前期的发生,有较高的敏感度及特异度。

sFlt-1 and Flt-1 belong to the vascular endothelial growth factor receptor（VEGFR）,sFlt-1 competition binding with VEGF,completely abolished the biological activity of VEGF,inhabited angiogenesis and affected the vascular wall barrier integrity and permeability.Placental growth factor（PLGF） is a member of the VEGF family,PLGF binds with Flt-1 receptor,and promotes angiogenesis and trophoblast proliferation.These biological functions can be blocked by sFlt-1 receptor,sFlt-1 plays an important role in regulate PLGF.sFlt-1 concentrations are higher in preeclampsia serum and prior to the onset of the disease.Levels of PLGF are lower in preeclampsia serum compare to normal.sFlt-1 plays a major role in the pathogenesis of preeclampsia,it is unclear how hypoxia regulates placental sFlt-1 expression,maybe the PI3K-Akt pathway plays an important role in regulating the expression of sFlt-1.sFlt-1 and PLGF might be used as markers for predicting preeclampisa.