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间充质干细胞治疗炎症性心肌病的研究进展 被引量：1

Research progress of mesenchymal stem cells treating inflammatory cardiomyopathy
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摘要 炎症性心肌病是一种慢性渐进性疾患,传统的治疗方法不能改变其心衰的结局,寻求有效治疗策略成为目前研究重点。众多证据表明干细胞移植可改善心功能,其中间充质干细胞(mesenchymal stem cells,MSCs)还具有免疫抑制特性,使其在治疗炎症性心肌病时具有独特优势。现就炎性感染如何诱发MSCs的功能、如何促使其归巢到受损心肌、静脉应用MSCs的可行性作一综述。 Inflammatory cardiomyopathy usually has a progressive course, conventional therapy can not alert the pathological process for heart failure, merging for alternative interventional strategies is necessary. There is accumulating support for the application of cellular transplantation as a strategy to improve myocardial function, Mesenchymal stem cells （MSCs） have the advantage over other stem cells that they possess immunomodulatory features, making them attractive candidates for the treatment of inflammatory cardiomyopathy. This paper gives an overview about how inflammation triggers the functionality of MSCs and how it induces cardiac homing. Finally, the potential of intravenous application of MSCs by inflammatory cardiomyopathy is discussed.
作者 瞿海龙 边剑飞 周英莲 杨伟红 麻晓静 梁璐
机构地区 河北大学附属医院急诊科 保定市南市区妇幼医院
出处 《医学研究与教育》 CAS 2012年第3期44-48,共5页 Medical Research and Education
关键词 间充质干细胞 炎症性心肌病 归巢 mesenchymal stem cells inflammatory cardiomyopathy homing
分类号 R542.2 [医药卫生—心血管疾病]
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参考文献20

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二级参考文献20

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医学研究与教育
2012年 第3期

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