摘要
目的观察探讨类风湿关节炎(RA)患者Th1、Th2型细胞在患者病情演变中的特点,总结其临床意义。方法选取51例类风湿关节炎患者为观察组,分别在其治疗前和治疗后3个月进行Th1、Th2型细胞检测,再选取健康体检者60例为对照组,也进行同样的细胞检测,观察比较两组治疗前后的差异性。结果观察组治疗前与对照组比较,Th1型细胞显著高于对照组、Th2型细胞低于对照组,差异有统计学意义(P<0.05),观察组患者经过治疗后,其血清中Th1型细胞明显降低,而Th2型细胞明显升高,与治疗前比较有统计学意义(P<0.05)。结论对类风湿性关节炎患者进行Th1、Th2型细胞检测,能有助于判断患者的病情进展,对评价临床疗效及预测预后有重要的临床指导意义。
Objective To observe investigate patients with rheumatoid arthritis （RA） of Thl and Th2 cell characteristics in the evolution of the patient＇s condition, to summarize its clinical significance. Methods 51 cases of rheumatoid arthritis patients in the observation group, respectively, before treatment and 3 months after treatment of Thl and Th2 cell detection, and then select the 60 cases of healthy persons as control group, but also for the same cell detection compare the differences before and after treatment. Results The observation group before treatment compared with the control group of Th 1 cells was significantly higher than that of Th2-type cells than the control group, the difference was statistically significant （P〈0.05） observed in patients after treatment, the serum Th 1 type cells was significantly reduced, while the Th2 cells was significantly increased compared with before treatment was statistically significant （P〈0.05）. Conclusion For patients with rheumatoid arthritis ofThl, Th2 cell detection can help to judge the patient＇s progression to evaluate the clinical efficacy and predict prognosis have important clinical significance.
出处
《中国医药指南》
2012年第16期51-52,共2页
Guide of China Medicine
