血清VEGF水平在小细胞肺癌诊治中的临床意义

Clinical significance of serum vascular endothelial growth factor in patients with small cell lung cancer

目的探讨血清血管内皮生长因子(serum vascular endothelial growth factor,sVEGF)水平在小细胞肺癌(SCLC)诊治中的临床价值。方法用放射免疫的方法检测69例未经任何治疗的SCLC患者sVEGF水平以及治疗后的sVEGF水平,同时用相同方法检测了50例健康体检者的sVEGF水平作为对照,分析SCLC患者与健康体检者的sVEGF水平差异,并分析SCLC患者sVEGF水平与临床分期及治疗效果之间的关系。结果 SCLC组sVEGF水平[(236.83±72.35)ng/ml]明显高于健康对照组[(114.18±27.57)ng/ml,t=12.853,P<0.001],广泛期患者的sVEGF浓度[(263.09±81.30)ng/ml]高于局限期浓度[(204.63±42.04)ng/ml,t=-3.846,P<0.001],治疗有效组治疗后sVEGF水平[(129.43±29.12)ng/ml]低于治疗前[(236.90±68.76)ng/ml,P<0.05],治疗无效组治疗后sVEGF水平[(236.72±78.60)ng/ml]与治疗前[(258.70±72.93)ng/ml,t=-1.100,P=0.281]无明显变化。结论 sVEGF浓度检测有助于SCLC诊断,监测治疗前后SCLC患者sVEGF浓度变化对评价治疗效果具有积极的意义。

Objective To investigate the clinical value of serum vascular endothelial growth factor（VEGF） levels of patients in th diagnosis and treatment of small cell lung cancer（SCLC）.Methods The serum VEGF levels of 69 cases of SCLC and 50 cases of healthy volunteers were detected by radioimmunoassay before and after treatment.To analyze the difference of serum VEGF levels between the patients with SCLC and healthy volunteers,and analyze the serum VEGF levels of patients with SCLC in different clinical stages,and also analyze the relationship between the curative effect and serum VEGF levels.Results Serum VEGF level of patients with SCLC[（236.83±72.35） ng/ml] was obviously higher than control group[（114.18±27.57） ng/ml,t=12.853,P 0.001];Widely period small cell lung cancer[（263.09±81.30） ng/ml] higher than limited stage[（204.63±42.04） ng/ml,t=-3.846,P0.001].The serum VEGF level of effective treatment group[（129.43±29.12） ng/ml] is lower than before[（236.90±68.76） ng/ml,t=10.030,P0.001].The serum VEGF level of ineffective treatment group[（236.72±78.60） ng/ml] chang little than before[（258.70±72.93） ng/ml,t=-1.100,P=0.281].Conclusion The serum VEGF levels measurement is helpful to diagnose small cell lung cancer（SCLC）,and monitoring the serum VEGF levels changes of patients with SCLC before and after the treatment to judge the treatment effect of small cell lung cancer has a positive significance.